Abstract: 

The invention relates to potential native mechanisms of replication suppression of HCV related proteins in immuno-competent animal model, and the use of bovine cells for the virus replication studies.

Background: 

The invention relates to potential native mechanisms of replication suppression of HCV related proteins in immuno-competent animal model, and the use of bovine cells for the virus replication studies.

Benefits: 

This technology can result in the improvement on the knowledge of HCV origin and a new research models for HCV studies. Improvements in diagnostics and therapeutic of this disease in humans may be achieved since this animal model seams to provide a natural system that suppresses HCV proteins expression. The in vitro system using never described cultured cells can be a step forward on studies of HCV replication.

Potential comercial use/applications: 

Animal model for HCV pathogenesis studies: therapeutics and early diagnosis, and a cell culture model that can be used for in vitro studies of virus infection.