Therapeutic Agent and Analytical Probe for Cell Biology Studies sed in the Inhibition of the P53-MDM2 Interaction.
Therapeutic Agent and Analytical Probe for Cell Biology Studies sed in the Inhibition of the P53-MDM2 Interaction.
Favourable apparent permeability coefficients was obtained and no cytotoxicity was observed.
From commercial available building blocks only four steps are required for their synthesis; the synthesis was proven to be suitable for scale-up.
Therefore, these derivatives can be used as probes in the p53-signalling pathway reseach field involving the p53 interaction with its endogenous negative regulator MDM2. Additionally, a formulation containing these compounds as effective components may be used in the treatment of cancer.
Analytical probe for cell biology
Therapeutic compound
